Publications by authors named "I Fleidervish"
Measuring the action potential (AP) propagation velocity in axons is critical for understanding neuronal computation. This protocol describes the measurement of propagation velocity using a combination of somatic whole cell and axonal loose patch recordings in brain slice preparations. The axons of neurons filled with fluorescent dye via somatic whole-cell pipette can be targeted under direct optical control using the fluorophore-filled pipette.
View Article and Find Full Text PDFVoltage-gated sodium channels located in axon initial segments (AIS) trigger action potentials (AP) and play pivotal roles in the excitability of cortical pyramidal neurons. The differential electrophysiological properties and distributions of Na1.2 and Na1.
View Article and Find Full Text PDFTraumatic brain injury (TBI) is a serious condition that is associated with an increased risk of severe, long-term psychiatric consequences. Drugs that target the glutamatergic system have proven successful in treating both TBI and many of its psychiatric sequelae. Blood glutamate scavengers (BGS) cause a decrease in blood glutamate levels, leading to a reduction in glutamate's concentration gradient from the brain to the blood and decreased levels of brain glutamate.
View Article and Find Full Text PDFTraumatic brain injury (TBI) is associated with significant cognitive and psychiatric conditions. Neuropsychiatric symptoms can persist for years following brain injury, causing major disruptions in patients' lives. In this review, we examine the role of glutamate as an aftereffect of TBI that contributes to the development of neuropsychiatric conditions.
View Article and Find Full Text PDFArticle Synopsis
- Depression is a major cause of disability globally, and traditional antidepressants often have delayed effects, undesirable side effects, and limited long-term success.
- Recent research suggests new glutamate-based therapies, such as blood glutamate scavengers, could offer alternative treatment options for major depressive disorder.
- The review emphasizes the need to explore the glutamate system's role in depression, especially in conditions with impaired blood-brain barrier permeability, advocating for further investigation into these novel therapeutic approaches.