Pancreatic and hepatic balances of endogenous insulin and of glucose in the anaesthetized dog during primed and non-primed infusions of glucose and of mannitol.

Simultaneous monitoring of pancreatic and hepatic blood flows and serial analyses of blood glucose and immunoreactive insulin activity in arterial, portal, intestinal and hepatic venous blood were performed in anaesthetized laparotomized dogs. Based on these measurements, the rates of pancreatic insulin secretion, of hepatic insulin uptake and the hepatic glucose balance were computed. Under basal conditions pancreatic output was about 40% of the total hepatic insulin input.