Publications by authors named "I Farmer"
Article Synopsis
- - The study explores how verbal and nonverbal skills impact children's numerical development, particularly comparing preterm-born (PTB) and term-born children, revealing that PTB kids are more likely to struggle with certain numerical tasks like cardinality.
- - Individual differences in both groups show that while verbal and nonverbal skills influence numerical performance, their effects vary significantly based on gestational age, with stronger verbal skills leading to better performance in older preterm children.
- - By focusing on individual differences rather than just group averages, the research highlights the importance of understanding unique developmental paths to better identify risk and protective factors in children's numerical learning.
Article Synopsis
- The review discusses the recent advancements in treating Systemic Mastocytosis (SM), emphasizing the significance of targeting the C-KIT D816V mutation as identified by the WHO.
- New therapeutic options like Avapritinib and other potent KIT tyrosine kinase inhibitors (TKIs) have shown promise in achieving long-term remissions and improving patient outcomes with minimal side effects.
- The review also highlights the role of molecular profiling in tailoring combination therapies for SM, especially when associated with other hematologic conditions, and presents clinical cases to illustrate these treatment strategies.
Background: Infants with exomphalos major have a high mortality and morbidity. The aims of this study were to identify predictors of survival regardless of the size of the exomphalos, and to analyze morbidity in infants with exomphalos minor.
Methods: Patients were classified as having exomphalos major or minor based on whether the liver was in the exomphalos sac, and the size of the abdominal wall defect.
Introduction: Strategies to improve the efficacy of endocrine agents in breast cancer (BC) therapy and to delay the onset of resistance include concomitant targeting of the estrogen receptor alpha (ER) and the mammalian target of rapamycin complex 1 (mTORC1), which regulate cell-cycle progression and are supported by recent clinical results.
Methods: BC cell lines expressing aromatase (AROM) and modeling endocrine-sensitive (MCF7-AROM1) and human epidermal growth factor receptor 2 (HER2)-dependent de novo resistant disease (BT474-AROM3) and long-term estrogen-deprived (LTED) MCF7 cells that had acquired resistance associated with HER2 overexpression were treated in vitro and as subcutaneous xenografts with everolimus (RAD001-mTORC1 inhibitor), in combination with tamoxifen or letrozole. End points included proliferation, cell-cycle arrest, cell signaling, and effects on ER-mediated transactivation.