Laryngeal Myxoglobulosis: A Rare Histologic Variant of Mucocele. The First Reported Case.

Myxoglobulosis is a rare histologic variant of mucocele that is characterized by transformation of mucin into eosinophilic globules. The globules frequently demonstrate a lamellar pattern and are surrounded by an inflammatory cell infiltrate. Myxoglobulosis has not yet been described in laryngeal mucosa.

Computational fluid-structure interaction simulation of airflow in the human upper airway.

Obstructive sleep apnoea syndrome (OSAS) is a breathing disorder in sleep developed as a consequence of upper airway anatomical characteristics and sleep-related muscle relaxation. Fluid-structure interaction (FSI) simulation was adopted to explain the mechanism of pharyngeal collapse and snoring. The focus was put on the velopharyngeal region where the greatest level of upper airway compliance was estimated to occur.

Sleep magnetic resonance imaging with electroencephalogram in obstructive sleep apnea syndrome.

Objective: To evaluate the mechanism and level of upper airway obstruction in obstructive sleep apnea (OSA) patients during natural sleep, together with synchronous electroencephalogram and respiratory events registration at 3-Tesla magnetic resonance imaging (MRI) platform with high spatial and temporal resolution.

Study Design: A prospective cohort study of 20 randomly selected OSA patients.

Methods: Fifteen of 20 patients were able to complete spontaneous sleep during MRI.

TPF induction chemotherapy and concomitant irradiation with cisplatin and cetuximab in unresectable squamous cell carcinoma of the head and neck.

Background: The purpose of this study was to assess the efficacy and toxicity of docetaxel, cisplatin/5-fluorouracil (TPF) induction chemotherapy and concomitant immunochemoradiotherapy with cetuximab and cisplatin in unresectable head and neck carcinoma.

Methods: Treatment consisted of TPF induction chemotherapy (docetaxel 75 mg/m(2) day 2; cisplatin, 75 mg/m(2) day 2; and 5-fluorouracil 750 mg/m(2) days 1-4; 4 cycles), followed by radiotherapy (RT) and concomitant weekly cetuximab, (250 mg/m(2), after a loading dose of 400 mg/m(2)) and cisplatin (30 mg/m(2)).

Results: Twenty-five of 30 patients completed 4 cycles of induction chemotherapy.

Epiglottoplasty for reconstruction of defects after laryngectomy with partial pharyngectomy.

Objectives: We present a novel use of sliding epiglottoplasty as an alternative method for closing mucosal defects in selected laryngectomies with partial pharyngectomy.

Methods: Sliding epiglottoplasty as described and advocated by Sedlacek, Bouche, Kambic, and Tucker for reconstruction in partial laryngectomies was used to close the defects after laryngectomy with partial pharyngectomy in 17 patients with advanced hypopharyngeal cancers as primary therapy (16 patients) and as post-radiochemotherapy therapy (1 patient).

Results: All reconstructions were successful.