Does nivolumab for progressed metastatic lung cancer fulfill its promises? An efficacy and safety analysis in 20 general hospitals.

Objectives: In patients with refractory or recurrent non-small-cell lung cancer (NSCLC) after first line chemotherapy, phase III trials showed superiority of nivolumab, an IgG4 programmed death-1 immune-checkpoint-inhibitor antibody, over docetaxel. We evaluated case mix, effectiveness and safety of nivolumab upon implementation in general practice.

Materials And Methods: In 20 general hospitals, all consecutive NSCLC patients treated with nivolumab within the medical need program (inclusion period 12 months) in Flanders - Belgium were evaluated.

'Some' Effects of Age, Task, Task Content and Working Memory on Scalar Implicature Processing.

In three experiments, we investigated the effect of age, task, task content and working memory (WM) on scalar implicature processing. We found that three-year-olds still often interpret the scalar term 'some' logically (some being compatible with all), but five-year-olds and especially seven-year-olds are highly competent pragmatic reasoners. Additionally we found that not only the nature of the task but also the specific task content influences the number of pragmatic answers: an Action-Based-Task (ABT) leads to more pragmatic answers than a metalinguistic Truth-Value Judgment Task (TVJT) that, in turn, leads to more pragmatic answers than a different TVJT that includes more cognitive content.

The influence of tocolytic drugs on cardiac function, large arteries, and resistance vessels.

Purpose: Beta-2 adrenoceptor agonistic drugs like ritodrine have been the reference tocolytic drugs, but are associated with cardiovascular side-effects. Atosiban, a newer drug, is a competitive antagonist of oxytocin and has been claimed to have fewer cardiovascular side effects. Until now, there has mainly been a subjective reporting of adverse reactions and few objective cardiovascular data.

Different effects of tocolytic medication on blood pressure and blood pressure amplification.

Background: The importance of tocolysis has been discussed extensively. Beta-2 adrenoceptor agonistic drugs like ritodrine have been the reference tocolytic drugs in most countries. Cardiovascular side-effects are frequent.

Diagnosis and treatment of hypertensive disorders during pregnancy.

Pregnancy is a cardiovascular and metabolic challenge to the human female body. This review summarizes current knowledge on the regulation of blood pressure and plasma volume in normal and hypertensive pregnant women. During pregnancy, systemic vascular resistance and blood pressure decrease, whereas cardiac output and blood volume increase to safeguard an adequate circulation in the utero-placental arterial bed.