Global changes in extreme tropical cyclone wave heights under projected future climate conditions.

Tropical cyclone risks are expected to increase with climate change. One such risk is extreme ocean waves generated by surface winds from these systems. We use synthetic databases of both historical (1980-2017) and future (2015-2050) tropical cyclone tracks to generate wind fields and force a computationally efficient wave model to estimate significant wave heights across all global tropical cyclone basins.

Comment on "Which Portion of Physiotherapy Treatments' Effect Is Not Attributable to the Specific Effects in People With Musculoskeletal Pain? A Meta-analysis of Randomized Placebo-Controlled Trials" by Ezzatvar et al.

Letter to the Editor-in-Chief in response to JOSPT article "Which Portion of Physiotherapy Treatments' Effect Is Not Attributable to the Specific Effects in People With Musculoskeletal Pain? A Meta-analysis of Randomized Placebo-Controlled Trials" by Ezzatvar et al .

Supplementation of Olive Oil and Flaxseed Oil on Blood Pressure and Inflammation in Healthy and At-Risk Adults: A Systematic Literature Review and Meta-Analysis.

Background: Adding olive oil (OO) and flaxseed oil (FLO) to the diet has been reported to improve endothelial function and reduce inflammation. However, the efficacy of supplementing OO and FLO on blood pressure (BP) in normo-, pre-, and hypertensive stage 1 adults is uncertain.

Objective: This study aimed to systematically review the literature on OO and FLO supplementation on BP and select inflammatory markers in healthy adults and adults at risk of hypertension.

Biophysical characterization of blood coagulation factor VIII binding to lipid nanodiscs that mimic activated platelet surfaces.

Background: Following proteolytic activation, activated blood coagulation factor (F)VIII (FVIIIa) binds to activated platelet membranes, forming the intrinsic tenase complex with activated FIX (FIXa). Previous studies have identified the C1 and C2 domains as the membrane binding domains of FVIII through conserved arginine residues. A membrane binding model for the FVIII C domains proposes that surface-exposed hydrophobic and positively charged residues at each C domain interact with the membrane, yet a comprehensive thermodynamic and structural description of this interaction is lacking.