Areolar reconstruction: MICAP flap as a skin paddle donor site in skin sparing mastectomy and implant-based reconstruction.

The main advantage of preserving the nipple-areola complex (NAC) in small to moderate size breasts reconstruction is that the main diameters of the breast mound remain unaltered. When for oncological reason the NAC must be excised, a paddle of skin needs to be borrowed from a donor site and transferred into the surgical defect to maintain the breast contour. While this is easily achievable with the majority of autologous reconstructions, it is very challenging in the context of implant-based reconstructions, where the primary closure of the defect leads to a flattened breast mound and suboptimal cosmetic results.

H/ACA snRNP-dependent ribosome biogenesis regulates translation of polyglutamine proteins.

Stem cells in many systems, including germline stem cells (GSCs), increase ribosome biogenesis and translation during terminal differentiation. Here, we show that the H/ACA small nuclear ribonucleoprotein (snRNP) complex that promotes pseudouridylation of ribosomal RNA (rRNA) and ribosome biogenesis is required for oocyte specification. Reducing ribosome levels during differentiation decreased the translation of a subset of messenger RNAs that are enriched for CAG trinucleotide repeats and encode polyglutamine-containing proteins, including differentiation factors such as RNA-binding Fox protein 1.

Long term results of treatment of breast cancer without axillary surgery - Predicting a SOUND approach?

Background: Traditionally axillary surgery has been used to provide staging information and until recently was thought to improve loco-regional control. However, a more minimal approach to the axilla is now being adopted. The aim of this study was to assess long term outcomes of patients with 'low-risk' breast cancers who did not undergo any axillary surgery.

Lipomodelling for the management of symptomatic peristomal contour abnormalities: a pilot and feasibility study.

Aim: Lipomodelling has been successfully used in reconstructive breast surgery but not yet in patients with permanent stomas.

Method: A feasibility study of six patients with permanent stomas was undertaken. Patients underwent lipomodelling of the peristomal area.

Role of lipomodelling in improving aesthetic outcomes in patients undergoing immediate and delayed reconstructive breast surgery.

Aims: The objective of this article is to report our findings regarding large-volume fat transfer in patients who have undergone autologous breast reconstruction with the latissimus dorsi (LD) flap and/or implant-based reconstruction with subsequent lipomodelling for symmetrisation.

Methods: We retrospectively collected data on all patients who have undergone lipomodelling from October 2008 to October 2011. Fat was harvested using a low-negative pressure syringe method and centrifuged at 3000 r.