[Polymorphism of the gene of heat shock protein hsp70 in lines of rats with normal and hypertensive status].

RFLP in the hsp70 gene encoding a major heat shock protein was analyzed in rat strains with high and normal arterial blood pressure. Dimorphism in the sets of DNA fragments was revealed after hybridization of the hsp gene leader sequence with rat DNA digested with BamHI restriction endonuclease. Type I RFLP was represented by the fragments of 12,200, 6500, 41,000 and 1600 bp in size.

[Characterization of rat lines with normotensive and hypertensive status using genomic fingerprinting].

The properties of normotensive and hypertensive rat lines were investigated by the DNA fingerprinting method using a multilocus micro-satellite (CAC)5 probe. The HaeIII and HinfI restriction endonucleases were found to be the most informative enzymes in this case. The high genetic homogeneity of the ISIAH line, a rat line with inherited stress-sensitive arterial hypertension created at the Institute of Cytology and Genetics, was demonstrated.