[Ability of erythrocytes to deposit thyroid hormones: regulatory role of physico-chemical factors in vitro].

Data obtained suggest the existence of regulation mechanism controlling parameters of thyroid status, that does not require any modification of thyroid gland secretory function. The realisation of this mechanism can involve hormone-depositing function of blood erythrocytes, which is sensitive to a) change of regional or systemic pH and b) change of hematocrit. Results of the present study indicate that mammalian erythrocytes are able to bind considerable quantities of T3 and T4 and, T3 binding is preferable.

[Lipid peroxidation and the role of quaternary ammonium compounds in normalizing this process].

Regulation of lipid peroxidation is realized not only by antioxidant enzymes but by natural antioxidants as well. We have lately succeeded, together with the students, in identifying antioxidant properties of quaternary ammonium compounds, which fact makes it possible for the above properties to gain extensive applicability in a setting where there is this variety of disbolism. One of such drug preparations is ethonium.

[The mechanism of action of the bioflavonoid lespeflan and the antihypoxant TB-4 on nitrogen metabolism in animals with acute kidney failure].

The changes in the levels of urea and creatinine caused by the new native preparation lespeflanum and the antihypoxant TB-4 were studied in animal experiments. The agents tested produced a significant hypoazotemic effect in acute renal failure. Lespeflanum showed diuretic and natriuretic effects in healthy animals, elevated plasma aldosterone levels and decreased hepatic arginase activity.

[The antioxidant activity of bis-quaternary ammonium compounds of the methylene series].

Experiments on albino rats were made to reveal antioxidant activity of bisquaternary ammonium compounds of the methylene series (ethonium, thionium and dodeconium). It is determined by the enhancement of superoxide anion radicals neutralization and splitting of lipoperoxides.

[New tableted protein products in the treatment of peptic ulcer patients and the dynamic indices of the glutathione system].

The authors investigated the content of reduced glutathione, activity of glutathione peroxidase, glutathione transferase, glutathione reductase, glucoso-6-phosphate dehydrogenase in the liver tissue, gastric mucosa of rats with experimental ulcer and in the blood of patients with gastric and duodenal ulcer in the course of treatment using new protein tableted products. Experimental investigations were conducted on 96 white rats, clinical studies in 128 patients and 59 healthy persons. It was shown that high therapeutic efficiency of these new tableted products, their normalizing effects on the glutathione system indices are important.