Publications by authors named "I F Lopez"
Purpose: Patients receiving immunotherapy need to have a good understanding of how immunology works and which toxicities they can expect. This study aimed to assess patients' knowledge on their immunotherapies and their quality of life before and after receiving immunotherapy for the first time in a cancer centre.
Methods: From July 2018 to September 2020, all patients treated at the cancer centre receiving first-time immunotherapy were invited to participate in a cross-sectional descriptive study.
Article Synopsis
- The Open Targets Platform is an open-source knowledge base designed for identifying and prioritizing drug targets with enhanced data and tools.
- Significant updates include a revamped target-disease associations page featuring interactive elements and a new Target Prioritisation view, allowing users to evaluate targets based on clinical relevance and safety.
- The platform now also incorporates a direction of effect assessment from various evidence sources, illustrating how genetic variations impact target functions, thereby aiding in the understanding of disease treatment mechanisms.
Laryngeal dystonia and vocal tremor response to botulinum toxin injection.
Eur Arch Otorhinolaryngol
December 2024
Purpose: The main objective of this study was to compare laryngeal dystonia (LD) and vocal tremor's (VT) response to botulinum toxin injection.
Methods: Retrospective study including every patient with LD or VT injected with botulinum toxin guided by electromyography, from January 1, 2010, to September 30, 2022, at a tertiary hospital centre. Improvement was assessed with the VHI-10, grade of dysphonia in a visual analogue scale (VAS; 0-10), GRBAS(I) scale (0-3) and maximum phonation time (MPT).
Emerging research suggests that exposures to metals during pregnancy and consequent disruptions in gut microbiome (GM) are associated with depressive disorders in childhood. , a GM bacteria, has been studied for its potential antidepressant effects. However, its role in influencing the association between prenatal metal exposures and depressive symptoms during childhood is unknown.
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- T cell therapies, like CAR and TCR T cells, are emerging cancer treatments, but improving their effectiveness requires understanding their behavior in populations.
- The authors developed advanced tools using live-cell imaging to track and analyze modified T cells interacting with tumor cells, focusing on their morphology, movement, and interactions.
- They found that specific genetic modifications in TCR T cells led to longer interaction times and better activation against cancer cells, while other modifications increased T cell growth, paving the way for more effective cancer therapies.