Publications by authors named "I F Kovalenko"
Human mesenchymal stromal cells (MSCs) are attractive for both medical practice and biomedical research. Nonfreezing short-term storage may provide safe and simple transportation and promote the practical use of MSCs. We aimed to determine the duration of efficient storage at ambient temperature (22°C) of human dermal MSCs in different three-dimensional organization and to investigate the role of cell metabolic mode in the resistance to the ambient storage damaging factors.
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- Plastocyanin is a small protein that helps transfer electrons by forming temporary complexes with cytochrome and photosystem 1, making traditional structure determination difficult.
- Due to its transient nature, researchers have turned to AI, particularly AlphaFold 3, to predict the structures of these short-lived complexes.
- The study found that the structure predicted by AlphaFold 3 closely matched experimental data from cryo-EM and molecular dynamics, whereas it differed from the orientation suggested by previously available NMR data.
Genomic surveillance detected clonal sequence type-361 isolates carrying , , , and from a patient in Ukraine and four wounded foreign soldiers evacuated to Germany. Isolates were non-susceptible to carbapenems, aminoglycosides, and cefiderocol and aztreonam/avibactam due to a PBP3 YRIN insertion and the AmpC β-lactamase. Coordinated surveillance efforts across civilian, military, and veteran healthcare systems are essential to prevent further spread as international volunteers return home after medical evacuation from Ukraine.
View Article and Find Full Text PDFThe Role of Hydroxyeicosatetraenoic Acids in the Regulation of Inflammation in Bronchial Asthma.
Dokl Biochem Biophys
September 2024
Hydroperoxyeicosatetraenoic acids (HETEs) are metabolites of arachidonic acid that are oxidized by a family of enzymes including cyclooxygenase, lipoxygenase, and cytochrome P450 enzymes. These enzymes are widely present in various organs and tissues, and the HETEs they synthesize perform an important function in the regulation of immune reactions and haemostasis processes under physiological and pathophysiological conditions. More researchers confirm the role of these oxidized metabolites in modulating inflammation in asthma.
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- - The study investigates the link between obesity and breast cancer characteristics in underserved populations in the U.S., focusing on safety-net hospitals.
- - It analyzed data from 927 breast cancer patients, highlighting significant associations between body mass index (BMI), menopausal status, and disease stage at diagnosis, particularly in postmenopausal women.
- - Findings indicated that obesity is associated with larger tumor sizes and more advanced lymph node involvement in postmenopausal patients, with higher obesity rates reported in African American patients.