Publications by authors named "I F Gosselink"
Background: Inhalation is one of the main exposure routes to nanoplastics. Knowledge of the toxicological impact of nanoplastics on the airway- and lung epithelium is limited and almost exclusively based on submerged in vitro models using spherical polystyrene (PS) particles.
Methods: Mono-cultures and advanced (co-)cultures of human bronchial- and alveolar epithelial cells, all air-liquid interface (ALI) cultures, were exposed to nanoplastics and reference nanoparticles.
Article Synopsis
- * Researchers identified a specific gene, ID1, that plays a critical role in the transformation process by affecting gene expression and the morphology of melanocytes, indicating its contribution to the early stages of melanoma.
- * The study's findings suggest that there are clinically undetectable precursors to melanoma that exhibit distinct traits and that targeting these precursors could lead to improved methods for early diagnosis and prevention of the disease.
Inhalable Textile Microplastic Fibers Impair Airway Epithelial Differentiation.
Am J Respir Crit Care Med
February 2024
Microplastics are a pressing global concern, and inhalation of microplastic fibers has been associated with interstitial and bronchial inflammation in flock workers. However, how microplastic fibers affect the lungs is unknown. Our aim was to assess the effects of 12 × 31 μm nylon 6,6 (nylon) and 15 × 52 μm polyethylene terephthalate (polyester) textile microplastic fibers on lung epithelial growth and differentiation.
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