Publications by authors named "I F De Coo"

Introduction: Primary open-angle glaucoma (POAG) is a characteristic optic neuropathy, caused by degeneration of the optic nerve-forming neurons, the retinal ganglion cells (RGCs). High intraocular pressure (IOP) and aging have been identified as major risk factors; yet the POAG pathophysiology is not fully understood. Since RGCs have high energy requirements, mitochondrial dysfunction may put the survivability of RGCs at risk.

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We aimed to provide a detailed phenotypic description of status epilepticus (SE) in a large cohort of patients with POLG disease and identify prognostic biomarkers to improve the management of this life-threatening condition. In a multinational, retrospective study with data on patients with POLG disease from seven European countries, we identified those who had SE. The age of SE onset, accompanying clinical, laboratory, imaging and genetic findings were analysed.

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Article Synopsis
  • A study called L-ICON evaluated the long-term effectiveness and safety of occipital nerve stimulation (ONS) for chronic cluster headache after a successful 48-week ICON trial.
  • Out of 103 eligible participants, a significant majority were followed for over two years, showing a remarkable decrease in weekly headache attacks compared to baseline, with many reporting sustained improvement even after five years.
  • Most participants expressed a positive experience, with 78% reporting subjective improvement and 81% willing to recommend ONS to others, although half experienced complications requiring additional surgery.
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Primary open-angle glaucoma (POAG) is characterized by optic nerve degeneration and irreversible loss of retinal ganglion cells (RGCs). The pathophysiology is not fully understood. Since RGCs have a high energy demand, suboptimal mitochondrial function may put the survival of these neurons at risk.

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Phelan-McDermid syndrome (PMS) is a 22q13.3 deletion syndrome that presents with a disturbed development, neurological and psychiatric characteristics, and sometimes other comorbidities like seizures. The epilepsy manifests itself in a variety of seizure semiologies.

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