High-throughput tracking enables systematic phenotyping and drug repurposing in disease models.

There are thousands of Mendelian diseases with more being discovered weekly and the majority have no approved treatments. To address this need, we require scalable approaches that are relatively inexpensive compared to traditional drug development. In the absence of a validated drug target, phenotypic screening in model organisms provides a route for identifying candidate treatments.

Mid-term outcomes using a 'kinematic retaining' total knee replacement - A multicentre prospective study at five years follow-up.

Background: Although total knee replacement (TKR) surgery has succeeded in improving pain and deformity, a proportion of patients remain incompletely satisfied with their outcome. This prospective study aims to assess the survivorship, clinical, and radiological outcomes using a novel 'kinematic retaining' (KR) implant.

Methods: 156 patients underwent TKR surgery for primary osteoarthritis using the Physica KR implant at three European Centres.

Orthorexia nervosa versus healthy orthorexia: Anxiety, perfectionism, and mindfulness as risk and preventative factors of distress.

Background: Orthorexia nervosa is a recently conceptualised pathological entity presenting as an obsessive focus on healthy eating with associated psychosocial impairment.

Aims: The present study investigated the differential associations between orthorexia nervosa and healthy orthorexia with distress and impairment.

Materials & Methods: With a community sample (N = 268) multiple measures of orthorexia nervosa and health orthorexia were compared as explanatory variables in mediation structural equation modelling (SEM).

The zebrafish mutant implicates sodium homeostasis in sleep regulation.

Sleep is a nearly universal feature of animal behaviour, yet many of the molecular, genetic, and neuronal substrates that orchestrate sleep/wake transitions lie undiscovered. Employing a viral insertion sleep screen in larval zebrafish, we identified a novel gene, (), whose loss results in behavioural hyperactivity and reduced sleep at night. The neuronally expressed gene is conserved across vertebrates and encodes a small single-pass transmembrane protein that is structurally similar to the Na,K-ATPase regulator, FXYD1/Phospholemman.

Predictors of long-term survival in 5,680 patients admitted to a UK major trauma centre with thoracic injuries.

Introduction: The long-term outcomes of chest trauma are largely unknown. We sought to determine the predictors of in-hospital and long-term survival in patients admitted to a major trauma centre (MTC) with chest injuries and to evaluate spatial patterns of injury in our network area.

Methods: Retrospective analysis of data collected on the National Trauma Audit Research Network (TARN) database using multivariate analysis and Cox regression analysis.