3D Imaging Reveals Complex Microvascular Remodeling in the Right Ventricle in Pulmonary Hypertension.

Background: Pathogenic concepts of right ventricular (RV) failure in pulmonary arterial hypertension focus on a critical loss of microvasculature. However, the methods underpinning prior studies did not take into account the 3-dimensional (3D) aspects of cardiac tissue, making accurate quantification difficult. We applied deep-tissue imaging to the pressure-overloaded RV to uncover the 3D properties of the microvascular network and determine whether deficient microvascular adaptation contributes to RV failure.

Characterizing the Spatiotemporal Transcriptomic Response of the Right Ventricle to Acute Pressure Overload.

This study analyzed microarray data of right ventricular (RV) tissue from rats exposed to pulmonary embolism to understand the initial dynamic transcriptional response to mechanical stress and compare it with experimental pulmonary hypertension (PH) models. The dataset included samples harvested from 55 rats at 11 different time points or RV locations. We performed principal component analysis (PCA) to explore clusters based on spatiotemporal gene expression.

Dynamic Heterogeneities in Liquid Mixtures Confined in Nanopores.

Binary liquid mixtures can exhibit nanosegregation, albeit being fully miscible and homogeneous at the macroscopic scale. This tendency can be amplified by geometrical nanoconfinement, leading to remarkable properties. This work investigates the molecular dynamics of -butanol (TBA)-toluene (TOL) mixtures confined in silica nanochannels by quasielastic neutron scattering and molecular dynamics simulation.

Microstructure of nonideal methanol binary liquid mixtures.

The nonideality of binary mixtures is often related to the nature of the interactions between both liquids and of the heterogeneity at the nanoscale-named microstructure. When one of the liquids is a hydrogen bonds former and the second is aprotic, the progressive diluting of the hydrogen-bonding network leads to a clustering and nanophases. By considering two mixtures, toluene-methanol and cyclohexane-methanol, the nonideality and its connection with the structure at the nanoscale and the intermolecular interactions are numerically investigated.

Free Energy of Nucleation and Interplay between Size and Composition in CuNi Systems.

Using molecular simulation, we shed light on the crystal nucleation process in systems of Cu, Ni, and their nanoalloy. For each system, we simulate the formation of the crystal nucleus along the entire nucleation pathway and determine the free energy barrier overcome by the system to form a critical nucleus. Comparing the results obtained for the pure metals to those for the nanoalloy, we analyze the impact of alloying on the free energy of nucleation, as well as on the size and structure of the crystal nucleus.