Publications by authors named "I Epstein"
Article Synopsis
- - Enfortumab vedotin (EV) is effective for patients with advanced urothelial carcinoma who have previously received platinum chemotherapy and immune therapy, despite lacking research on those treated with avelumab maintenance.
- - A study of 182 patients showed a median overall survival of 12.7 months and a progression-free survival of 7.9 months, with 39% achieving a positive response to EV after avelumab treatment.
- - The study confirms EV's effectiveness, suggesting it can be a viable option for patients previously treated with avelumab, with manageable side effects like grade ≥ 3 neuropathy and skin rash occurring in a minority of cases.
In many countries, such as Canada, the USA, England, and Australia, to graduate from a regulated profession such as nursing, students must complete a set of work-integrated learning (WIL) hours and demonstrate their ability to safely perform physical skills and apply knowledge in relation to professional standards. For a disabled nursing student (DNS) undergoing training in higher education institutions (HEI), securing proper accommodations to participate effectively in WIL experiences has been difficult due to concerns related to risks to self and patient safety. This study used critical discourse analysis to investigate the framing of risk and safety in association with providing DNS with accommodation in WIL.
View Article and Find Full Text PDFAssociation of Tumor Mutational Burden and Microsatellite Instability With Response and Outcomes in Patients With Urothelial Carcinoma Treated With Immune Checkpoint Inhibitor.
Clin Genitourin Cancer
December 2024
Article Synopsis
- - The study investigated the relationship between Tumor Mutational Burden (TMB) and Microsatellite Instability (MSI) status in patients with urothelial carcinoma (UC) receiving immune checkpoint inhibitors (ICI), focusing on overall survival (OS).
- - Results showed that patients with a higher TMB (≥10 mut/Mb) generally experienced longer median OS compared to those with lower TMB, although these differences weren't always statistically significant.
- - Notably, patients treated with maintenance avelumab had a significantly better OS when TMB was high (61 months vs. 17 months for low TMB), indicating potential benefits of ICI based on TMB and MSI status, warranting further investigation.
We investigate the emergence of Turing patterns in a system growing as a rotating spiral in two dimensions, utilizing the photosensitivity of the chlorine dioxide-iodine-malonic acid (CDIMA) reaction to control the growth process. We observe the formation of single and multiple (double and triple) stationary spiral patterns as well as transitional patterns. From numerical simulations of the Lengyel-Epstein model with an additional term to account for the effects of illumination on the reaction, we analyze the relationship between the final morphologies and the radial and angular growth velocities, identify conditions conducive to the formation of transitional structures, examine the importance of the size of the initial nucleation site in determining the spiral's multiplicity, and evaluate the stability and robustness of these Turing patterns.
View Article and Find Full Text PDFThe Koper model is a prototype system with two slow variables and one fast variable that possesses small-amplitude oscillations (SAOs), large-amplitude oscillations (LAOs), and mixed-mode oscillations (MMOs). In this article, we study a pair of identical Koper oscillators that are symmetrically coupled. Strong symmetry breaking rhythms are presented of the types SAO-LAO, SAO-MMO, LAO-MMO, and MMO-MMO, in which the oscillators simultaneously exhibit rhythms of different types.
View Article and Find Full Text PDF