Publications by authors named "I El Meouche"
Introduction: Cefiderocol is a siderophore cephalosporin active in vitro against carbapenemase-producing Enterobacterales, including New Delhi metallo-β-lactamases (NDM-1). A significant impact of the size of bacterial inoculum on its efficacy has been described in vitro, the clinical impact of which is unclear. Here, we analyse the inoculum effect of cefiderocol against E.
View Article and Find Full Text PDFA common feature of bacterial, fungal and cancer cell populations upon treatment is the presence of tolerant and persistent cells able to survive, and sometimes grow, even in the presence of usually inhibitory or lethal drug concentrations, driven by non-genetic differences among individual cells in a population. Here we review and compare data obtained on drug survival in bacteria, fungi and cancer cells to unravel common characteristics and cellular pathways, and to point their singularities. This comparative work also allows to cross-fertilize ideas across fields.
View Article and Find Full Text PDFArticle Synopsis
- Urinary tract infections (UTIs), primarily caused by E. coli, are common and often recur even after antibiotic treatments, posing a challenge for effective management.
- Researchers used a synthetic reporter to observe E. coli cell division in a UTI mouse model, finding that bacteria were more actively dividing in the kidneys and urine than in the bladder, while those surviving antibiotics were consistently non-dividing.
- The study highlights the importance of understanding how different bacterial strains and their environments affect infection persistence and treatment response, which could lead to better strategies for combating recurrent UTIs.
Article Synopsis
- Temocillin is a specific antibiotic effective against multi-drug resistant Enterobacterales, but its resistance mechanisms are not well understood, especially in Escherichia coli strains studied here.
- Researchers analyzed both susceptible and resistant E. coli strains, focusing on genetic mutations and their effects on temocillin effectiveness in lab tests and a mouse infection model.
- Results showed that while temocillin was generally effective against certain resistant strains, one strain (CFTbaeS-AP) proved completely resistant, indicating that high minimum inhibitory concentration (MIC) values don't always predict antibiotic effectiveness.
Background: Antimicrobial drugs are mostly studied for their impact on emergence of bacterial antibiotic resistance, but their impact on the gut microbiota is also of tremendous interest. gut models are important tools to study such complex drug-microbiota interactions in humans.
Methods: The MiniBioReactor Array (MBRA) microbiota system; a single-stage continuous flow culture model, hosted in an anaerobic chamber; was used to evaluate the impact of three concentrations of a third-generation cephalosporin (ceftriaxone) on faecal microbiota from two healthy donors (treatment versus control: three replicates per condition).