Impact of antimicrobial stewardship in organisms causing nosocomial infection among COVID-19 critically ill adults.

Objective: To evaluate the implementation of an antibiotic stewardship program in critically ill COVID-19 patients and to establish risk factors for coinfection. Secondary objective was to analyze the evolution of the etiology of respiratory nosocomial infections.

Methods: Single-center observational cohort study of consecutive patients admitted to ICU due to COVID-19 pneumonia from March 2020 to October 2022.

Statin therapy prior to hospitalization does not significantly influence sepsis presentation or sepsis outcomes. A prospective, observational study.

Background: In addition to being effective at lowering cholesterol, statins seem to have immunomodulatory, antimicrobial, antioxidant and anticoagulant effects.

Objective: To determine whether the presentation of sepsis and its outcome in patients who have had prehospital statin therapy are different.

Methods: A prospective, observational study was carried out on 1042 septic patients, for 5 consecutive years in the Intensive Care Unit (ICU) of a tertiary hospital.

Epidemiology and prognostic factors in severe sepsis/septic shock. Evolution over six years.

Objective: To determine the clinical characteristics and prognostic factors of patients with severe sepsis/septic shock admitted to the Intensive Care Unit of Donostia University Hospital (Guipuzcoa, Spain).

Design: A prospective, observational study was carried out during a consecutive 6-year period (1st February 2008-31st December 2013).

Setting: The Intensive Care Unit of Donostia University Hospital, the only third level hospital in the province of Guipuzcoa, with a recruitment population of 700,000 inhabitants.