Parameters of stress response at various stages of postresuscitation period.

Transient circulatory arrest (10 min) was followed by changes in rat adrenals and thymus and a decrease in blood calcium and protein contents typical of stress response. Maintenance under unfavorable conditions for a long time also produced changes in stress-target organs accompanied by a considerable shift in functional state of the central nervous system manifested in enhanced behavioral response to exogenous stimulation.

Behavioral reactions of rats in the early postresuscitation period after systemic circulatory arrest of different duration.

Rats were exposed to systemic circulatory arrest for 10, 12, and 15 min. During the first 10 days after resuscitation exploratory activity of animals depended on the duration of systemic circulatory arrest and was determined by two opposite factors: high reactivity of the central nervous system contributing to intensification of exploratory activity, and impaired general state of survivors (inhibition of animal behavior).

Some reasons for modifications of rat's conditioned behavior after resuscitation.

In rats survived systemic circulatory arrest and resuscitation, pathological changes such as increased excitability of the central nervous system and decreased volume of simultaneously acquired information considerably modulate conditioned activity. The interaction between these factors facilitates learning after formation of targeted behavioral pattern.

[Effect of perftoran on post-resuscitation recovery of the central nervous system].

The effect of perfluorane on survival and restorative process in the brain were studied in rats subjected to 12-min arrest of systemic circulation. Perfluorane in a single dose of 5-10 ml/kg was injected intraperitoneally 30 min after the beginning of reanimation. The drug did not affect the postreanimation death of animals and time course of neurologic deficiency disappearance.

[Post-resuscitation neurosomatic deviations and the feasibility of their correction with a drug of metabolic action].

Circulation in white rat males was stopped for 10 minutes by ligation of the intrathoracic vascular bundle of the heart. Proxipin in a dose 10 or 20 mg/kg was injected i.p.