Pulmonary consequences of experimentally induced stroke: differences between global and focal cerebral ischemia.

Introduction: Cerebral ischemia leads to multiple organ dysfunctions, with the lungs among the most severely affected. Although adverse pulmonary consequences contribute significantly to reduced life expectancy after stroke, the impact of global or focal cerebral ischemia on respiratory mechanical parameters remains poorly understood.

Methods: Rats were randomly assigned to undergo surgery to induce permanent global cerebral ischemia (2VO) or focal cerebral ischemia (MCAO), or to receive a sham operation (SHAM).

[Perspectives of next generation sequencing in the microbiological evaluation and treatment of dog bites].

Az antibiotikum-rezisztencia a modern orvoslás egyre több kihívást adó problémája. A kutyaharapás gyógyításának számos esetben elengedhetetlen része az antibiotikus kezelés. Az eredményes gyógyításhoz minél hamarabb ismerni kellene a kórokozókat és azok antibiotikum-érzékenységét.

Senolysis potentiates endothelial progenitor cell adhesion to and integration into the brain vasculature.

Background: One of the most severe consequences of ageing is cognitive decline, which is associated with dysfunction of the brain microvasculature. Thus, repairing the brain vasculature could result in healthier brain function.

Methods: To better understand the potential beneficial effect of endothelial progenitor cells (EPCs) in vascular repair, we studied the adhesion and integration of EPCs using the early embryonic mouse aorta-gonad-mesonephros - MAgEC 10.

Evaluation of the Effectiveness and Safety of Mesenchymal Stem Cell Treatment in Fistulising Crohn's Disease: An International Real-Life Retrospective Multicentre Cohort Study.

Background: Perianal fistulas of Crohn's disease (CD) create a significant burden on patients' lives. However, the efficacy and safety of adipose-derived mesenchymal stem cell treatment are contradicting, and real-world evidence is lacking.

Aims: To examine the usability of darvadstrocel therapy in managing perianal CD.

Relationships between capnogram parameters by mainstream and sidestream techniques at different breathing frequencies.

Capnography, routinely used in operating rooms and intensive care units, reveals essential information on lung ventilation and ventilation-perfusion matching. Mainstream capnography directly measures CO in the breathing circuit for accurate analysis and is considered a reference technique. Sidestream capnography, however, analyzes gas away from the patient leading to potentially less accurate measures.