Late-onset relapsing neurotoxicity after Brexucabtagene autoleucel associated with high chimeric antigen receptor T cells in cerebrospinal fluid.

Background Aims: Mounting evidence suggests that persistent cell expansion is the main driver for both efficacy and toxicity of chimeric antigen receptor (CAR) T-cell therapy. Hereby, we describe a case of delayed recurrent neurotoxicity associated with late CAR T-cells re-expansion.

Case Description: A 44-year-old man suffering from mantle cell lymphoma received brexu-cel.

A hydrophobic deep eutectic solvent-based microextraction for the determination of ultra-trace arsenic in foods by an electrothermal atomization atomic absorption spectrometry.

A hydrophobic deep eutectic solvent-based liquid-phase microextraction approach for the determination of ultra-trace arsenic (total) in foods by an electrothermal atomization atomic absorption spectrometry was developed. Various deep eutectic solvents based on tetraoctylammonium bromide and fatty acids (heptanoic, octanoic, nonanoic, decanoic acids) were studied as extraction solvents for preconcentration of arsenic (V) from mineralizates obtained after a microwave digestion of food samples. Phenomenon of ion-pairs formation between dihydroarsenate and precursor of deep eutectic solvent (tetraoctylammonium) and mass-transfer of the ion-pairs into deep eutectic solvent phase was presented for the first time.

Russian collection of vaccine strains: annotation, implementation and genomic analysis.

Over the past 10 years, immunization of cattle in Russia has been performed using vaccines from strains 82, 19 and 75/79. To prevent brucellosis in small ruminants, two vaccines have been used, from the strain REV-1 and the strain 19; note that twice as many animals have been immunized with the former vaccine than with the latter vaccine. The disadvantage of using these preparations is the formation of prolonged post-vaccination seropositivity, which is especially pronounced in animals after immunization with vaccines from strain 19 and strain REV-1.

Oral and periodontal assessment at the first trimester of pregnancy: The PERISCOPE longitudinal study.

Introduction: Periodontal diseases (gingivitis and periodontitis) are chronic non-communicable inflammatory diseases. The risk of developing gingivitis and periodontitis increases during pregnancy. Also, periodontitis increases the risk of developing adverse pregnancy outcomes such as preterm birth and preeclampsia.

Whole-genome sequencing of strains isolated in Russia.

Background And Aim: is a Gram-negative bacterium belonging to the family that can cause bovine histophilosis. may act as a commensal or opportunistic bacterial cattle pathogen. Comparing genomes of the pathogenic strain 2336 with the non-pathogenic preputial 129Pt isolate revealed some putative virulence factors.