Sex differences in blood pressure responses of Pekin ducks to sound stimuli and conspecific vocalizations.

We tested Pekin ducks with playbacks of 5 different vocalizations plus a no noise and white noise stimulus as our controls (N = 15 ducks/sex/treatment). The "AM long" call is a common vocalization made by both sexes. "Honk" is also produced by both sexes and is thought to be an alarm or distress call.

Preclinical Evaluation of Bavdegalutamide (ARV-110), a Novel PROteolysis TArgeting Chimera Androgen Receptor Degrader.

Androgen receptor (AR) signaling is the principal driver of prostate cancer, and drugs that target this pathway (e.g., abiraterone and enzalutamide) are standard treatments for metastatic hormone-sensitive prostate cancer and metastatic castration-resistant prostate cancer (mCRPC).

The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology.

Amino acid substitutions in the kinase domain of the human CSF1R protein are associated with autosomal dominant adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP). To model the human disease, we created a disease-associated mutation (Glu631Lys; E631K) in the mouse Csf1r locus. Previous analysis demonstrated that heterozygous mutation (Csf1r) had a dominant inhibitory effect on CSF1R signaling in vitro and in vivo but did not recapitulate human disease pathology.

Differences in motivational dynamics between experienced cyclists and untrained participants during an incremental endurance exercise task.

Purpose: The conflict between the desire to reduce effort during exercise and the performance goal of the exercise task contributes to explaining endurance exercise performance. However, whether the trajectories of these two motivational responses systematically differ across individuals with different characteristics is poorly understood. The present study examined whether changes in desire to reduce effort and performance goal value across moderate, heavy, and severe exercise intensity domains differed between cyclists and untrained, but active participants.