Social housing effects of Intermittent Access of Methamphetamine Self-administration and social behavior.

Unlabelled: Social support is a potentially protective factor against substance use disorders (SUDs). Previous studies in animal models for SUDs have shown that when females are pair housed, they have lower motivation for cocaine and methamphetamine (METH), than females who are single housed. In males, however, social housing has not had the same beneficial effect.

Effects of Social Housing on Electrically Stimulated Dopamine Release in the Nucleus Accumbens Core and Shell in Female and Male Rats.

Dopamine (DA) is a neurotransmitter that is important in the reward system and increased DA release is associated with rewarding properties of drugs. Highly addictive stimulants like methamphetamine (METH) increase DA release and block reuptake, causing the DA to stay in the synapse longer, enhancing its effects. Because the misuse of METH is increasing in the United States, it is important to investigate ways to protect against this highly addictive stimulant.

Integrating Tobacco Treatment Into Lung Cancer Screening: The Screen Assist Factorial Randomized Clinical Trial.

Importance: Integrating tobacco treatment into lung cancer screening (LCS) could increase smoking cessation among older smokers by leveraging a teachable moment and treatment access.

Objective: To identify effective evidence-based tobacco treatment components for individuals undergoing LCS.

Design, Setting, And Participants: A 2 × 2 × 2 factorial randomized clinical trial offered to adults aged 50 to 80 years who spoke English or Spanish and were scheduled for LCS at 11 outpatient imaging sites from April 2019 to June 2023.

The role of cellular senescence in endothelial dysfunction and vascular remodelling in arteriovenous fistula maturation.

Haemodialysis (HD) is often required for patients with end-stage renal disease. Arteriovenous fistulas (AVFs), a surgical procedure connecting an artery to a vein, are the preferred vascular access for HD due to their durability and lower complication rates. The aim of AVFs is to promote vein remodelling to accommodate increased blood flow needed for dialysis.