[Neuroprotective potential of pyrimidine-4-H1-OHa derivatives in experimental cerebral ischemia].

Objective: To evaluate the effect of ten pyrimidine-4-H1-OH derivatives on the change in the activity of mitochondrial respiratory chain complexes and tricarboxylic acid cycle enzymes in rats under experimental brain ischemia.

Material And Methods: Cerebral ischemia in rats was modeled by irreversible occlusion of the middle cerebral artery. Two hundred and sixty male Wistar rats were administered studied compounds at a dose of 50 mg/kg (orally) and the reference - L-carnitine at a dose of 200 mg/kg (orally) for 72 hours after ischemia modeling (once a day).