[Intensity of lipid peroxidation and its relation to changes in the composition and antioxidative properties of lipids in acute viral hepatitis].

Interrelationship between the patterns of lipid peroxidation (diene conjugates and the lipid antioxidative activity) and alterations in lipid composition (content of total lipids, phospholipids and cholesterol) was studied in blood serum of patients with acute viral hepatitis and in healthy donors. An increase in content of lipids in blood serum of the patients with the hepatitis but not the intensity of peroxidation reactions in lipids was found to be responsible for the increase in content of the lipid peroxidation products in blood serum. With an increase in severity of the disease relative content of phospholipids in the total lipid fraction as well as antioxidative activity of lipids were elevated, while relative content of cholesterol and level of lipid oxidation were lowered.

[Role of bilirubin as a natural antioxidant in regulating lipid peroxidation intensity in acute viral hepatitis].

Elevation of the content of lipid peroxidation (LPO) products in blood serum of patients with acute virus hepatitis (VH) is caused by an increase in the patients' blood serum lipids rather than by the intensity of peroxide reactions in lipids. There is a reverse correlation between the content of LPO products and bilirubin level and a direct correlation between lipid antioxidant activity (AOA) and bilirubin level. Marked antioxidant action of bilirubin that compares very favourably with the action of ionol (4-methyl-2,6-ditretbutylphenol) was demonstrated in the model of oxidation of methyl oleate.