[The role of alternative approaches to antiischemic therapy in patients with stable coronary artery disease].

Contemporary approach to antianginal therapy in patients with stable are reviewed. Benefits and limitations of "standard" antiischemic therapy and evidence-based data about alternative therapy with nicorandil are discussed in details.

[Restoration of the physical working capacity in the patients presenting with bronchial asthma and excessive body weight at the stage of therapy. A new medical technology].

The proposed technology of rehabilitative treatment of the patients presenting with bronchial asthma and excessive body weight is based on the selective approach and physical rehabilitation programs adapted to the specific requirements of individual patients. It is shown that the dosed high-intensity physical exercises with the use of ergo-training simulators make up a safe and efficacious tool for the treatment of overweight asthmatic patients.

[SAYP interacts with DHR3 nuclear receptor and participates in ecdysone-dependent transcription regulation].

The role of metazoan coactivator SAYP in nuclear receptor-driven gene activation in the ecdysone cascade of Drosophila is considered. SAYP interacts with DHR3 nuclear receptor and activates the corresponding genes by recruiting the BTFly (Brahma and TFIID) coactivator supercomplex. The knockdown of SAYP leads to a decrease in the level of DHR3-activated transcription.

[Novel conservative domain of SAYP coactivator mediates TFIID and Brahma transcriptional complexes interaction].

In the S2 cell system of Drosophila melanogaster a key protein domain mediating the interaction of TFIID and Brahma transcriptional complexes into the BTFly supercomplex has been shown to be an evolutionary conserved SAY domain of the SAYP. TFIID and Brahma coactivators participated in the reporter gene activation induced by the SAY domain in cellular nuclei. The TFIID and Brahma components directly interacting with the SAY domain were identified.