Publications by authors named "I E Kushnir"
Primary hyperparathyroidism is a common endocrinopathy. Multiple Endocrine Neoplasia Type 1 (MEN1) is a rare autosomal dominantly inherited endocrine tumor predisposition syndrome, with one of main manifestations being primary hyperparathyroidism. We retrospectively evaluated a set of 1011 patients who underwent surgery for primary hyperparathyroidism between the years 2018-2022, and found 78 (8 %) patients who underwent reoperations and 27 patients with MEN1 syndrome.
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- * PectaSol-Modified citrus pectin (P-MCP), an FDA-recognized safe food supplement, has shown promise in improving prostate-specific antigen doubling time (PSADT) in 75% of patients after 6 months of treatment.
- * In a second phase of a study lasting 12 months, 85% of patients maintained a long-term response to P-MCP, with significant improvements in PSA levels and safety, confirming its potential effectiveness and safety for BRPC-M0 patients.
Background: Erdafitinib, a fibroblast growth factor receptor (FGFR) inhibitor is a standard post chemotherapy advanced treatment line for metastatic urothelial carcinoma harboring FGFR2/3 genomic alterations. It was approved based on a phase 2 clinical trial, revealing a 40% response rate, and 13.8 months overall survival.
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- Life-prolonging therapies (LPTs) for advanced prostate cancer are becoming more prevalent, but the factors influencing patient access in real-world settings are not well understood.
- A study examined 3,575 prostate cancer patients in Ontario who died between 2013 and 2017, finding that 40.4% received LPT, with usage increasing yearly, especially among those treated at Regional Cancer Centers and those who had prior prostate therapy.
- Key factors affecting LPT access included age, chronic health conditions, and residence in long-term care, while income and distance to care did not play a significant role.
Investigating the effect of bacteriophages on bacterial FtsZ localisation.
Front Cell Infect Microbiol
August 2022
is one of the most common Gram-negative pathogens and is responsible for infection leading to neonatal meningitis and sepsis. The FtsZ protein is a bacterial tubulin homolog required for cell division in most species, including . Several agents that block cell division have been shown to mislocalise FtsZ, including the bacteriophage λ-encoded Kil peptide, resulting in defective cell division and a filamentous phenotype, making FtsZ an attractive target for antimicrobials.
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