Early Morphological and Functional Reorganization of the Articular Cartilage in Rats with Experimental Osteoarthrosis of Different Genesis.

Peculiarities of the morphology of some phenotypes of experimental osteoarthrosis was studied in experiments on rats. Reorganization of the knee articular cartilage of Wistar rats during aging (age-associated phenotype), obesity (metabolic phenotype), circulatory disturbances (e.g.

Morphology of Synovial Membrane and Articular Cartilage in the Knee Joint in Experimental Chronic Heart Failure.

Structural-and-functional reorganization of the synovial membrane and articular cartilage in the knee joint was studied in rats with experimental chronic heart failure. Separation of fibers, decrease in the relative volume density of microcirculatory vessels, and increase in the expression of MMP-9 and caspase 3 were found in the synovial membrane. A decrease in the thickness of the surface layer (tendency to erosion), vacuolization and necrosis of chondrocytes, and increase in their readiness to programmed cell death were observed in the articular cartilage.

[Determination of C-peptide, serum insulin, and characteristics of tissue insulin resistance in patients with osteoarthrosis].

A hundred and seventy-nine patients with osteoarthrosis (OA) (mean age 50.48+/-5.81 years) were examined for metabolic syndrome (MS) from the International Diabetic Federation (IDF) criteria in the groups with normal and increased fasting C-peptide levels.

[Metabolic syndrome and a course of osteoarthrosis].

Aim: To compare osteoarthritis (OA) course in patients with metabolic syndrome (MS) and those free of MS.

Material And Methods: The presence and completeness of MS according to 2005 criteria were studied in 1350 OA patients (mean age 52.65 +/- 11.

[Metabolic syndrome and rheumatic diseases].

Aim: To characterize prevalence and features of rheumatic diseases in patients with metabolic syndrome, metabolic disturbances in patients with rheumatic diseases (RD), to ascertain their most frequent variants and characteristics.

Material And Methods: After examination of 1291 therapeutic patients 19 to 79 years of age for metabolic syndrome (MS), those with MS were screened for RD. In parallel, 1212 RD patients were studied for associated pathology: arterial hypertension, coronary heart disease, obesity, dyslipidemia, hyperuricemia and other components of MS.