Publications by authors named "I E Kochevar"
Article Synopsis
- Erythropoietic protoporphyria (EPP) causes painful sensitivity to light, impacting patients' quality of life, and researchers aimed to create a wearable device to measure light exposure.
- A pilot study involved five EPP patients using two different light dosimeters over three weeks to assess their light exposure levels.
- Findings indicated that increased exposure to blue light significantly raised the risk of symptoms, with the wristband device showing a predictive accuracy of 78%, suggesting it could effectively help manage EPP symptoms.
Importance: Erythropoietic protoporphyria (EPP) is a rare and underdiagnosed genetic disease characterized by painful sensitivity to light. A better understanding and characterization of its light-induced cutaneous symptoms may aid in the identification of EPP in patients.
Objectives: To describe the cutaneous symptoms of erythropoietic protoporphyria (EPP) and to determine if these symptoms are associated with the degree of light sensitivity.
Photosensitized crosslinking of proteins in tissues has many medical applications including sealing wounds, strengthening tissues, and beneficially altering tissue properties. Rose Bengal (RB) is used most frequently as the photosensitizer but is not as efficient as would be desired for broad utilization in medicine. Aggregation of RB, at the high concentrations used for medical treatments, decreases the yield of singlet oxygen, which mediates protein crosslinking.
View Article and Find Full Text PDFRose bengal photodynamic antimicrobial therapy (RB-PDAT) treats corneal infection by activating rose bengal (RB) with green light to produce singlet oxygen (O). Singlet oxygen dosimetry can help optimize treatment parameters. We present a O dosimeter for detection of O generated during experimental RB-PDAT.
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