Publications by authors named "I E Flesch"
Occupational exposure to pollutants may cause health-damaging effects in humans. Genotoxicity assays can be used to detect the toxic effects of pollutants. In the present study, we evaluated genetic damage in three populations occupationally exposed to benzene, pyrenes, and agrochemicals and assessed the possible influence of titanium (Ti) co-exposure.
View Article and Find Full Text PDFThe expanding number of rare immunodeficiency syndromes offers an opportunity to understand key genes that support immune defense against infectious diseases. However, analysis of these in patients is complicated by their treatments and comorbid infections, requiring the use of mouse models for detailed investigations. We developed a mouse model of DOCK2 immunodeficiency and herein demonstrate that these mice have delayed clearance of herpes simplex virus type 1 (HSV-1) infections.
View Article and Find Full Text PDFThe expanding number of rare immunodeficiency syndromes offers an opportunity to understand key genes that support immune defence against infectious diseases. However, patients with these diseases are by definition rare. In addition, any analysis is complicated by treatments and co-morbid infections requiring the use of mouse models for detailed investigations.
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- The aging German population is leading to an increase in hospitalized patients' average age, making them more susceptible to complications and infections, particularly surgical site infections (SSI).
- In a study conducted from 2014 to 2018, researchers followed 345 SSI patients, evaluating various risk factors, demographics, and comorbidities to calculate mortality risks linked to age and health conditions.
- The results showed a significant increase in SSI patients from 2010 to 2019, especially in those under 65, with a marked rise in mortality risk after age 60, indicating that a 60-year-old with SSI has a similar mortality risk to that of an 80-year-old in the general population.
Rural children are exposed to several chemicals. This study evaluated the environmental co-exposure of rural children to cholinesterase inhibitor insecticides and metals/metalloids, and the resulting oxidative stress and DNA damage. Seventy-two children (5 to 16 years old) were studied at two different moments: period 1, when agrochemicals were less used, and period 2, when agrochemicals were extensively used in agriculture.
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