Publications by authors named "I E Efremova"
Background: Sarcopenia and gut dysbiosis are common in cirrhosis. The aim is to study the correlations between the gut microbiota taxa and muscle mass level in cirrhosis.
Methods: The study included 40 cirrhosis patients including 18 patients with sarcopenia.
Article Synopsis
- * Specific cytokines such as IL-1b, IL-6, and TNF-a were associated with both higher levels of harmful gut bacteria and the severity of cirrhosis symptoms like ascites, suggesting a connection between gut health and liver disease progression.
- * The results indicate that certain gut bacteria populations correlate directly with inflammatory cytokine levels, pointing to a potential link between gut dysbiosis and systemic inflammation in cirrhosis patients.
Background: The gut-liver axis and bacterial translocation are important in cirrhosis, but there is no available universal biomarker of cellular bacterial translocation, for which presepsin may be a candidate.
Aim: To evaluate the relationship of the blood presepsin levels with the state of the gut microbiota in cirrhosis in the absence of obvious infection.
Methods: This study included 48 patients with Child-Pugh cirrhosis classes B and C and 15 healthy controls.
Gut dysbiosis and subclinical intestinal damage are common in cirrhosis. The aim of this study was to examine the association of intestinal damage biomarkers (diamine oxidase [DAO], claudin 3, and intestinal fatty acid binding protein [I-FABP; FABP2]) with the state of the gut microbiota in cirrhosis. The blood levels of DAO were inversely correlated with blood levels of claudin 3, lipopolysaccharide (LPS), presepsin, TNF-α, and the severity of cirrhosis according to Child-Pugh scores.
View Article and Find Full Text PDFOur aim was to study the association of endothelial dysfunction biomarkers with cirrhosis manifestations, bacterial translocation, and gut microbiota taxa. The fecal microbiome was assessed using 16S rRNA gene sequencing. Plasma levels of nitrite, big endothelin-1, asymmetric dimethylarginine (ADMA), presepsin, and claudin were measured as biomarkers of endothelial dysfunction, bacterial translocation, and intestinal barrier dysfunction.
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