Publications by authors named "I E DE FORTEZA"

The emergence of antibiotic resistance necessitates not only the identification of new compounds with antimicrobial properties, but also new strategies and combination therapies to circumvent this growing problem. Here, we report synergistic activity against methicillin-resistant Staphylococcus aureus (MRSA) of the β-lactam antibiotic oxacillin combined with 7,8-dideoxygriseorhodin C in vitro. Ongoing efforts to identify antibiotics from marine mollusk-associated bacteria resulted in the isolation of 7,8-dideoxygriseorhodin C from a Streptomyces sp.

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The "wooden-steps" hypothesis [Distel DL, et al. (2000) 403:725-726] proposed that large chemosynthetic mussels found at deep-sea hydrothermal vents descend from much smaller species associated with sunken wood and other organic deposits, and that the endosymbionts of these progenitors made use of hydrogen sulfide from biogenic sources (e.g.

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Two new compounds, the peptide-polyketide glycoside totopotensamide A (1) and its aglycone totopotensamide B (2), were isolated from a Streptomyces sp. cultivated from the gastropod mollusk Lienardia totopotens collected in the Philippines. The compounds contain a previously undescribed polyketide component, a novel 2,3-diaminobutyric acid-containing macrolactam, and a new amino acid, 4-chloro-5,7-dihydroxy-6-methylphenylglycine.

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In a group of 130 patients carriers of cellulite, that were subjected to a general clinic treatment and local treatment of laser-therapy, the authors, previous to the therapeutics, made an anatomopathologic study of the skin and the adipose tissue. The biopsies were done on patients of the feminine sex, confirming that all these cases presented the histopathologic and histochemical features of cellulite in their dermo-hypodermic tissue. A full study of intolerance to carbohydrates; lipidic, proteic and hormonal metabolism was also performed in all patients.

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