Anticancer benzimidazole derivatives as inhibitors of epigenetic targets: a review article.

Cancer is one of the leading causes of morbidity and mortality worldwide. One of the primary causes of cancer development and progression is epigenetic dysregulation, which is a heritable modification that alters gene expression without changing the DNA sequence. Therefore, targeting these epigenetic changes has emerged as a promising therapeutic strategy.

Popularity and Perceptions of Protein Supplementation: A Cross-Sectional Study Among Undergraduate University Students Aged 18 to 25 Years in Riyadh, Saudi Arabia.

Background And Aim:  Young adults, particularly those aged 18-25, exhibit varying perceptions and choices regarding the use of protein supplements (PS). Understanding these perceptions can significantly enhance professional guidance and nutrition education for undergraduate students. This study, conducted in Riyadh, Saudi Arabia, aims to explore the perceptions of PS use and identify the most popular PS among university students.

Prosthetic Applications of Short Dental Implants in Limited Bone Height Cases: A Review Article.

The decision to rehabilitate insufficient alveolar bone height with short implants is considered an effective treatment. Complicated surgical procedures such as ridge augmentation, vestibuloplasty, and sinus lifting are usually accompanied by high risks such as membrane injury, hemorrhage, nerve affection, and increased time needed for implant treatment with unpredictable healing time. Short dental implants allow for faster treatment and decrease the need for complicated surgeries that are usually associated with standard dental implants, as in all four and all six concepts.

Advancements in skin grafting: Development and application of a novel two-blade dermatome for concurrent split-thickness and dermal graft harvesting.

This investigation delineates the evolution and prospective utilisation of an innovative two-blade dermatome, designed for the concurrent harvesting of a conventional split-thickness skin graft (STSG) and an additional dermal graft within the same surgical harvest. Historically, the extraction of dermal grafts has encountered substantial technical impediments, contributing to its limited acceptance and utilisation in clinical practice. The prototype dermatome, introduced in this technical note, offers a solution that could facilitate the more extensive adoption of dermal grafting techniques.

Piperine solubility enhancement via DES formation: Elucidation of intermolecular interactions and impact of counterpart structure via computational and spectroscopic approaches.

The development of new forms of existing APIs with enhanced physicochemical properties is critical for improving their therapeutic potential. In this context, ionic liquids (ILs) and deep eutectic solvents (DESs) have gained significant attention in recent years due to their unique properties and potential for solubility enhancement. In this study, we explore the role of different counterparts in the formation of IL/DESs with piperine (PI), a poorly water-soluble drug.