Publications by authors named "I Dutriez-Casteloot"
With advances in neonatal care, management of prolonged pain in newborns is a daily concern. In addition to ethical considerations, pain in early life would have long-term effects and consequences. However, its treatment remains inadequate.
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- * Findings indicate that maternal food restriction does not exacerbate metabolic issues caused by a high-fat diet, but leads to increased body weight and adiposity in offspring.
- * The research highlights changes in gene expression related to leptin and adipogenesis in white adipose tissue, suggesting that maternal undernutrition reprograms adult offspring's metabolic responses, potentially increasing their risk for obesity.
An association is established between schizophrenia and the development of metabolic alterations including cardiovascular diseases, type 2 diabetes and obesity. Perinatal insults, such as undernutrition, have been shown to increase the propensity to develop these pathologies, reinforcing the idea that schizophrenia may have a neurodevelopmental origin. Moreover, the use of second generation antipsychotics (SGAs) also known as "atypical" neuroleptics has also been demonstrated to exacerbate metabolic anomalies in patients with schizophrenia.
View Article and Find Full Text PDFInfluence of prenatal undernutrition on the effects of clozapine and aripiprazole in the adult male rats: relevance to a neurodevelopmental origin of schizophrenia?
Eur J Pharmacol
September 2011
Article Synopsis
- Maternal undernutrition may increase the risk of chronic diseases like metabolic syndrome and schizophrenia in offspring, implying these conditions have origins in early development.
- In a study comparing clozapine and aripiprazole treatments on 4-month-old male rats, both drugs affected metabolic and hormonal parameters differently in rats from food-restricted mothers (FR30) compared to controls.
- Although treatment didn't significantly alter body weight or food intake, clozapine notably reduced insulin secretion and plasma levels of leptin, corticosterone, and glucose in FR30 rats, suggesting these offspring have altered responses to atypical antipsychotics, potentially impacting their risk of metabolic disorders.
The brain-derived neurotrophic factor (BDNF) has been shown to exert an important role during implantation, placental development, and fetal growth control in mice. Its expression is closely related to the nutritional status in several tissues such as in the nervous system. In a previous study, we demonstrated that maternal undernutrition (MU), during the perinatal life, modified both the BDNF and its functional receptor, the tyrosine kinase receptor B (TrkB) gene expression in the brain of growth-restricted rat offspring during sensitive developmental windows, suggesting that these early modifications may have long-lasting consequences.
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