Publications by authors named "I Dumitriu"
Functional analysis of fibroblasts and macrophages in head and neck paragangliomas.
Front Endocrinol (Lausanne)
December 2024
Background And Aim: Head and neck paragangliomas (HNPGN) are tumours that carry significant morbidity The role of the stroma in the pathogenesis of HNPGN is not completely understood. This study explores the profile of fibroblasts and macrophages in HNPGN.
Methods: Ten patients undergoing HNPGN surgery were recruited.
Background: Vestibular schwannomas (VSs) remain a challenge due to their anatomical location and propensity to growth. Macrophages are present in VS but their roles in VS pathogenesis remains unknown.
Objectives: The objective was to assess phenotypic and functional profile of macrophages in VS with single-cell RNA sequencing (scRNAseq).
We have studied the fragmentation of the brominated cyclic hydrocarbons bromocyclo-propane, bromocyclo-butane, and bromocyclo-pentane upon Br(3d) and C(1s) inner-shell ionization using coincidence ion momentum imaging. We observe a substantial yield of CH fragments, whose formation requires intramolecular hydrogen (or proton) migration, that increases with molecular size, which contrasts with prior observations of hydrogen migration in linear hydrocarbon molecules. Furthermore, by inspecting the fragment ion momentum correlations of three-body fragmentation channels, we conclude that CH fragments (with x = 0, …, 3) with an increasing number of hydrogens are more likely to be produced via sequential fragmentation pathways.
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- Neurodevelopmental diseases like Tourette syndrome (TS) may involve issues with neural-immune interactions, potentially affecting brain development and stress responses.
- A study comparing 18 TS patients and 18 healthy volunteers found no significant differences in dendritic cell (DC) subsets, but noted increased MDC1s in TS patients with anxiety.
- The findings suggest that higher MDC1 frequencies in anxious TS patients could indicate proinflammatory conditions, and a negative correlation between MDC1 and brain metabolites implies a link between inflammation and metabolic changes in the brain.
Aims: Inflammation has important roles in atherosclerosis. CD4+CD28null (CD28null) T cells are a specialized T lymphocyte subset that produce inflammatory cytokines and cytotoxic molecules. CD28null T cells expand preferentially in patients with acute coronary syndrome (ACS) rather than stable angina and are barely detectable in healthy subjects.
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