Longitudinal analysis of anthropometric measures over 5 years in patients with Friedreich ataxia in the EFACTS natural history study.

Background: Friedreich ataxia is a rare neurodegenerative disorder caused by frataxin deficiency. Both underweight and overweight occur in mitochondrial disorders, each with adverse health outcomes. We investigated the longitudinal evolution of anthropometric abnormalities in Friedreich ataxia and the hypothesis that both weight loss and weight gain are associated with faster disease progression.

Origins of the substituent effects in the aldol condensation of axially chiral thiohydantoins: a computational study.

Aldol reactions are one of the most fundamental organic reactions involving the formation of carbon-carbon bonds that are commonly used in the synthesis of complex molecules through the condensation of an enol or enolate with a carbonyl group. The aldol reaction of thiohydantoin derivatives with benzaldehyde starts with hydrogen removal from C5 by lithium diisopropylamide (LDA) to form the enolate. Benzaldehyde adds to the enolate either at the less or more hindered site.

Impact of obesity on subarachnoid hemorrhage-induced cerebral vasospasm: An experimental rat model.

Aim: Obesity has emerged as a critical risk factor for various cerebrovascular diseases. Studies have demonstrated the detrimental effects of obesity on vascular health, including endothelial dysfunction, inflammation, and oxidative stress, which may exacerbate vascular complications following hemorrhagic stroke. In this study, the effect of obesity on the severity of cerebral vasospasm after subarachnoid hemorrhage was investigated.

Selenium, a Notable Micronutrient: A Crucial Element in the Context of All-Cause Long-Term Mortality in Renal Failure.

Selenium is a trace element involved in crucial antioxidative and anti-inflammatory processes in the body. Low selenium status has been linked to increased mortality due to compromised immune function and heightened risk of cardiovascular events. Patients with chronic kidney disease (CKD) face elevated mortality risks, prompting the need for strategies to mitigate these events.