Synthesis, X-ray crystal structure, Hirshfeld surface analysis, and molecular docking study of novel inhibitor of hepatitis B: methyl 4-fluoro-3-(morpholinosulfonyl)benzo[b]thiophene-2-carboxylate.

A method of 4-fluoro-3-(morpholinosulfonyl)benzo[b]thiophene-2-carboxylate synthesis has been developed and the electronic and spatial structure of a new biologically active molecule has been studied both theoretically and experimentally. The title compound was crystallized from acetonitrile and the single crystal X-ray analysis has revealed that it exists in a monoclinic P2/c space group, with one molecule in the asymmetric part of the unit cell. Hirshfeld surface analysis was used to study intermolecular interactions in the crystal.

IncobotulinumtoxinA in aesthetics: Russian multidisciplinary expert consensus recommendations.

Background: Although there are various international consensus recommendations on the use of botulinum neurotoxin type A (BoNT/A) in facial aesthetics, there are no global or Russian guidelines on the optimal dose of incobotulinumtoxinA, free from complexing proteins, within specific aesthetic indications. This article reports the outcomes of two expert consensus meetings, conducted to review and analyze efficacy and tolerability data for incobotulinumtoxinA in various facial aesthetic indications and to give expert consensus recommendations to ensure best clinical practice among Russian clinicians.

Methods: Thirteen dermatology and/or plastic surgery experts attended meetings held in Paris, France (November 2013), and Moscow, Russia (March 2014).

[Outpatient care of patients with atherosclerosis obliterans of lower limb arteries].

Results of application of complex treatment of patients with atherosclerosis obliterans of lower limb arteries by means of perfection of an out-patient stage of the surgical help are presented. Rendering assistance in the conditions of surgical branch of city polyclinic makes modern methods of conservative treatment for the overwhelming majority of patients with an obliterating atherosclerosis of arteries of the bottom extremities more accessible, promotes improvement of indicators of safety of extremities and survival rate of patients.

[Prevention of antibiotic-associated diarrhea in children].

One of the most frequent complications of antibiotic therapy is a diarrheal syndrome, which may be related both to the direct toxic effects of antibiotics on the gastrointestinal tract, and the activation of conditionally pathogenic intestinal flora. Particular attention gets to present the problem of C. difficile-infection, which may be the consequence of the development of pseudomembranous colitis in both children and adults.