Publications by authors named "I Dimauro"

Skeletal muscle tissue can regenerate after damage through the action of satellite cells, which proliferate as myoblasts when activated. Oxidative stress, marked by high rates of reactive oxygen species (e.g.

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Unlabelled: This study examines how power training affects estimated bone strength, revealing that females benefit more than males, especially in the upper limbs (radius). These findings highlight the importance of designing sex-specific exercise programs to enhance bone health. Further research is needed to optimize training duration and address site-specific differences.

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Muscle tissue is an important target of sex steroids, and particularly, testosterone plays essential roles in muscle cell metabolism. Wide ranges of studies have reported sex differences in basal muscle steroidogenesis, and recently several genes have been identified to be regulated by androgen response elements that show innate sex differences in muscle. However, studies accounting for and demonstrating cell sexual dimorphism in vitro are still scarce and not well characterized.

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Cancer remains a major challenge in medicine, prompting exploration of innovative therapies. Recent studies suggest that exercise-derived extracellular vesicles (EVs) may offer potential anti-cancer benefits. These small, membrane-bound particles, including exosomes, carry bioactive molecules such as proteins and RNA that mediate intercellular communication.

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Article Synopsis
  • Breast cancer (BC) is a major global health issue for women, and studies show that physical activity (PA) can significantly improve quality of life, recovery, and survival rates in BC patients.
  • PA affects DNA methylation, potentially reversing abnormal patterns linked to cancer and other diseases, and this review highlights how PA influences both global and gene-specific DNA methylation in BC patients.
  • The analysis indicates that PA can elevate global DNA methylation in tumors and affects various genes associated with important biological processes, underscoring its potential to restore normal cell function and improve recovery and survival outcomes for BC patients.
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