28-day oral toxicity study with soft corticosteroid BNP-166 in rats and dogs, followed by a 14-day recovery period.

The aim of the present study was to evaluate the soft corticosteroid BNP-166 in rats and dogs treated orally with 0.2, 2.0, and 20.

Study of the bone marrow penetration of radioactivity after oral administration of radiolabelled girisopam (EGIS-5810) in mice.

Girisopam (EGIS-5810) is a potent anxiolytic compound. Recent in vitro studies with the substance, in Chinese hamster ovary cells, indicated dose-dependent mutagenic activity. At the same time, in ex vivo bone marrow micronucleus tests performed after treating CFLP mice with extreme oral doses (875, 1300 and 1750 mg/kg) no mutagenic activity could be observed at any of the dose-levels.

[Pharmacokinetic studies of epervudine in rats using HPLC].

Pharmacokinetic properties of active substance of Hevizos ointment (Epervudine) were studied in rats after intravenous, oral and dermal applications. The animals received 10 mg/kg of Epervudine intravenously and orally. For checking of dermal absorption 220 mg of ointment (containing 0.

[Pharmacokinetic studies of 14C-labeled epervudine in rats].

The characteristics of absorption, distribution and elimination of 14C-labelled epervudine were studied in rats treated with 10 mg/kg doses orally and intravenously. The blood level curves were analyzed by appropriate pharmacokinetic models. The results of oral treatment showed a rapid absorption of the radioactivity from the gastrointestinal tracts of the animals (tmax (0.