Publications by authors named "I Demuth"

The immune system likely plays a key role in Parkinson's disease (PD) pathophysiology. Thus, we investigated whether immune cell compositions are already altered in healthy individuals at high genetic risk for PD. We quantified 92 immune cell subtypes in the blood of 442 individuals using multicolor flow cytometry.

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Aging is a complex process influenced by mechanisms operating at numerous levels of functioning. Multiple biomarkers of age have been identified, yet we know little about how the different alternative age indicators are intertwined. In the Berlin Aging Study II (nmin= 328; nmax= 1,517, women = 51%; 14.

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Article Synopsis
  • Blood-derived DNA methylation shows potential for early detection of dementia risk, linking biological factors with lifestyle and environmental influences.
  • A multivariate methylation risk score (MMRS) was developed, predicting mild cognitive impairment independently of age and sex, alongside significant future risk of cognitive decline in Alzheimer’s and Parkinson’s diseases.
  • The study highlights the integration of machine learning and omics data to enhance dementia risk prediction at the population level.
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  • A study explored the link between lipoprotein(a) [Lp(a)] levels and lung function in 679 relatively healthy older adults, finding that higher Lp(a) levels correlated with better lung function parameters.
  • Despite the initial findings indicating a positive association between Lp(a) and lung function, these results were not confirmed by Mendelian randomization analyses that utilized recent genome-wide study data.
  • The researchers suggest further investigation is needed due to the significant and possibly clinically relevant differences observed in lung function related to Lp(a) levels.
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Background: Severe hypertriglyceridemia (HTG) has predominantly multifactorial causes (MCS). Yet a small subset of patients have the monogenetic form (FCS). It remains a challenge to distinguish patients clinically, since decompensated MCS might mimic FCS´s severity.

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