Publications by authors named "I Degrieck"
Article Synopsis
- Severe aortic stenosis (AS) leads to changes in the heart’s left ventricle and can affect blood flow and resistance in coronary arteries.
- A study assessed coronary blood flow and microvascular resistance in AS patients before and after transcatheter aortic valve implantation (TAVI) and found no immediate changes right after the procedure.
- Six months post-TAVI, patients showed significant improvement in hyperaemic perfusion, indicating that over time, left ventricular remodelling positively affected blood flow during increased demand.
Minimally Invasive Pectus Excavatum Correction and Endoscopic Port Access Mitral Valve Surgery.
Rambam Maimonides Med J
January 2024
This case study describes the successful short-term outcome of staged minimally invasive pectus excavatum correction and endoscopic mitral valve repair in a patient with severe mitral valve regurgitation and pectus excavatum.
View Article and Find Full Text PDFAim: Cardiac remodelling plays a major role in the prognosis of patients with aortic stenosis (AS) and could impact the benefits of aortic valve replacement. Our study aimed to evaluate the expression of sodium-glucose cotransporter 2 (SGLT2) gene and protein in patients with severe AS stratified in high gradient (HG) and low flow-low gradient (LF-LG) AS and its association with cardiac functional impairments.
Methods And Results: Gene expression and protein levels of main biomarkers of cardiac fibrosis (galectin-3, sST2, serpin-4, procollagen type I amino-terminal peptide, procollagen type I carboxy-terminal propeptide, collagen, transforming growth factor [TGF]-β), inflammation (growth differentiation factor-15, interleukin-6, nuclear factor-κB [NF-κB]), oxidative stress (superoxide dismutase 1 [SOD1] and 2 [SOD2]), and cardiac metabolism (sodium-hydrogen exchanger, peroxisome proliferator-activated receptor [PPAR]-α, PPAR-γ, glucose transporter 1 [GLUT1] and 4 [GLUT4]) were evaluated in blood samples and heart biopsies of 45 patients with AS.
Background: Heart valve clinics (HVC) have been introduced to manage patients with valvular heart disease within a multidisciplinary team.
Objective: To determine the outcome benefit of HVC approach compared with standard of care (SOC) for patients with moderate and asymptomatic severe aortic stenosis (mAS and asAS).
Methods: Single-centre, observational registry of patients with mAS and asAS with at least one cardiac ambulatory consultation at our Cardiovascular Centre.