Publications by authors named "I Dedreux"
Our objective was to evaluate the contribution of monitoring B cell subset depletion after rituximab in patients with rheumatoid arthritis (RA) in order to guide reintroduction to forestall relapse. This prospective, monocentre study included all RA patients receiving two 1-g rituximab infusions at a 15-day interval. The patients were followed clinically and biologically every 2 months until rituximab reintroduction.
View Article and Find Full Text PDFObjective: To analyse the therapeutic effects of etanercept (ETA) or adalimumab (ADA) on the numbers and phenotypes of CD4+CD25hi Tregs in RA patients.
Methods: RA patients received ADA (n = 28) or ETA (n = 20) and stable-dose MTX or LEF. Therapeutic responses were assessed with the 28-joint DAS (DAS-28) criteria after 12 weeks of treatment.
Article Synopsis
- Peripheral blood stem cell transplantation (PBSCT) is an alternative to bone marrow transplantation (BMT), but the regulatory T cell (Treg) content in both types has not been thoroughly compared before.
- The study reveals that Treg frequencies are significantly lower in PBSC compared to BM transplants, with most Tregs in PBSC transplants displaying a phenotype associated with weak suppressive abilities.
- Factors like G-CSF administration and leukapheresis contribute to the reduction of functional Tregs, which may help explain the increased risk of graft-versus-host disease (GVHD) seen in PBSCT patients despite a higher infusion of T cells.