Elevated plasma levels of P-selectin glycoprotein ligand-1-positive microvesicles in patients with unprovoked venous thromboembolism.

Unlabelled: Essentials PSGL-1 microvesicles (MVs) may be important in venous thromboembolism (VTE). We measured plasma levels and parental origin of PSGL-1 MVs in patients with unprovoked VTE. VTE patients had higher plasma levels of PSGL-1 MVs than healthy controls.

Low biological cost of carbapenemase-encoding plasmids following transfer from Klebsiella pneumoniae to Escherichia coli.

Objectives: The objective of this study was to determine the biological cost, stability and sequence of two carbapenemase-encoding plasmids containing bla (pG12-KPC-2) and bla (pG06-VIM-1) isolated from Klebsiella pneumoniae when newly acquired by uropathogenic Escherichia coli clinical isolates of different genetic backgrounds.

Methods: The two plasmids were transferred into plasmid-free E. coli clinical isolates by transformation.

[The expert observation of myocardial contusion in a child].

A case of the myocardial contusion associated with the closed blunt chest injury in the girl aged 1 year 7 months is presented. The autopsy revealed hemorrhage of an irregular oval shape, coloured dark-red, and confined to the region with the area of 4.0 x 3.

Differential expression of plasma miRNAs in patients with unprovoked venous thromboembolism and healthy control individuals.

Background: Venous thromboembolism (VTE) remains the third most common cardiovascular disease with a vague pathogenesis. Circulating miRNAs are small regulatory RNAs found in plasma, serum and other body fluids in an apparently stable form. Although circulating miRNAs, a novel family of regulatory molecules, emerge as a promising class of biomarkers in many cardiovascular diseases and malignancies, knowledge on plasma miRNA levels in VTE remains sparse.

Costly Class-1 integrons and the domestication of the the functional integrase.

Class-1 integrons play an important role in the emergence and spread of antimicrobial resistance determinants. In a recent study we showed that host fitness was dramatically reduced following acquisition of these elements. These fitness costs were due to the presence of an active integrase and we suggested that the mechanistic explanation was due to reduced genetic stability through IntI1 mediated recombination events between / and non-canonical sites in the chromosome.