Maternal exposure to nicotine causes oxidative stress and inflammatory changes in the ovaries of adult rats' offspring.

Nicotine is one of the most toxic substances found in cigarettes, but also found in chewing tobacco gum, patches and vaping products (electronic cigarettes). In addition to being a highly addictive chemical, it is capable of reducing fertility in men and women. In the ovaries, it can induce morphological changes and impair the formation of follicles, being a possible cause of changes in the reproductive cycle and anticipation of menopause in women whose mothers smoked during pregnancy.

Chronic inflammatory demyelinating polyneuropathy associated with active systemic lupus erythematous: Anifrolumab as a potentially successful add-on therapy to intravenous immunoglobulins.

Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired, autoimmune peripheral neuropathy, rarely reported as being associated with systemic lupus erythematous (SLE). We report the case of 53-year-old women with a long history of SLE, diagnosed with CIDP during a lupus flare beginning with progressive muscle weakness of lower and upper limbs, without affection of the central nervous system. She received treatment with steroids, intravenous immunoglobulins and anifrolumab and showed clinical and immunological improvement.

Chemical and in vivo analyses of calcium silicate-based materials in bone and connective tissues.

Aim: Calcium silicate-based cements have been widely used in dentistry mainly due to their physicochemical and biological properties. Commercially available materials use radiopacifiers containing metals (bismuth, tantalum, tungsten and/or zirconium). To investigate volumetric changes, in vivo biocompatibility and systemic migration from eight commercially available materials, including powder/liquid and 'ready-to-use' presentations.

Systematic review of outcome measures used in support programs designed to enhance the functioning for autistic children and adolescents and ICF content mapping.

Purpose: 1) To identify outcome measures used in support programs designed to enhance functioning in autistic children and adolescents, and 2) To map the content of these measures to the domains of the International Classification of Functioning, Disability and Health (ICF).

Methods: A systematic review was conducted. Searches were performed in Medline/PubMed, EMBASE and Virtual Health Library databases, with no restrictions imposed regarding language or year of publication.

Groundwater releases CO to diverse global coastal ecosystems.

Coastal ecosystems play a major role in marine carbon budgets, but substantial uncertainties remain in the sources and fluxes of coastal carbon dioxide (CO). Here, we assess when, where, and how submarine groundwater discharge (SGD) releases CO to shallow coastal ecosystems. Time-series observations of dissolved CO and radon (Rn, a natural groundwater tracer) across 40 coastal systems from 14 countries revealed large SGD-derived CO fluxes.