Publications by authors named "I D Osipov"
Rationale: Cystic dilatation of the bulbourethral gland duct (Cowper's syringocele, CS) is a rare urethral pathology. No more than 150 cases of CS have been reported in the literature, of which the vast majority are children with a unilateral location. Bilateral CS has been reported in eight cases; however, detailed anatomy and clinical manifestations have not been reported.
View Article and Find Full Text PDFEfficacy and safety of single-agent belantamab mafodotin versus pomalidomide plus low-dose dexamethasone in patients with relapsed or refractory multiple myeloma (DREAMM-3): a phase 3, open-label, randomised study.
Lancet Haematol
October 2023
Article Synopsis
- Multiple myeloma is an incurable cancer with limited treatment options for patients whose disease has returned after previous therapies; belantamab mafodotin has shown promise in early studies for these patients.
- The DREAMM-3 phase 3 study involved 325 participants worldwide who were randomized to receive either belantamab mafodotin or a combination of pomalidomide and dexamethasone, with the main goal of evaluating progression-free survival.
- The study is ongoing, with patients recruited between April 2020 and April 2022, and it aims to determine the safety and efficacy of belantamab mafodotin compared to traditional treatments by September 2022.
Purpose: Investigation of the results of ureteral stricture single balloon dilation in children with primary obstructive megaureter.
Materials And Methods: Since 2012 to 2020 79 children (65 boys and 15 girls) with primary obstructive megaureter of II and III grades who had 92 affected ureters were operated on by method of ureteral stricture balloon dilation. Duration of postoperative stenting period was Me=68 [48; 91] days, bladder catheterization period - Me=15 [5; 61] days.
Revision surgery after previous spinal decompression and fusion for lumbar spinal stenosis.
Zh Vopr Neirokhir Im N N Burdenko
February 2023
Unlabelled: Nowadays, vertebral stenosis is the most common indication for surgical treatment in patients over 65 years old in spine surgery. According to the literature, there are conflicting data on the incidence and indications for revision surgery after previous spinal decompression and fusion for lumbar spinal stenosis.
Objective: To evaluate the incidence and indications for revision surgery after previous spinal decompression and fusion for lumbar spinal stenosis.
Human Adenovirus type 6 (HAdV-C6) is a promising candidate for the development of oncolytic vectors as it has low seroprevalence and the intrinsic ability to evade tissue macrophages. However, its further development as a therapeutic agent is hampered by the lack of convenient cloning methods. We have developed a novel technology when a shuttle plasmid carrying the distal genome parts with modified E1A and E3 regions is recombined in vitro with the truncated HAdV-C6 genome.
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