Computer-Assisted Modeling of Greater Tubercle Transposition Effect on Stress Distribution in Shoulder.

Background: The aim of the work was to investigate the influence of the position of a fractured greater tubercle of the humerus on stress distribution in the glenohumeral joint (GHJ) at shoulder abduction by performing stress-strain analysis (SSA).

Material And Methods: A simulated 3D model of the shoulder was constructed on the basis of anatomical and anthropometric data as close as possible to real ones using the SolidWorks software package.

Results: A finite-element model (FEM) was generated in a semi-automatic mode composed mostly of tetrahedral and hexagonal elements < 1 mm in dimensions.

Stage I Breast Cancer in the Modern Era: A Retrospective Cohort Study of 328 Patients Diagnosed from 2002 to 2006 with a 14-Year Median Follow-Up.

Introduction: This study aimed to evaluate the long-term outcomes of stage I breast cancer (BC) patients diagnosed during the current era of screening mammography, immunohistochemistry receptor testing, and systemic adjuvant therapy.

Methods: A retrospective cohort study was conducted on 328 stage I BC patients treated consecutively in a single referral center with a follow-up period of at least 12 years. The primary endpoints were invasive disease-free survival (IDFS) and overall survival (OS).

Finite Element Modeling of Chondrolabral Lesions in Pincer-Type Femoroacetabular Impingement.

Background: The prevalence of chondrolabral lesions due to femoroacetabular impingement (FAI) is 93% in cadaveric material. As a biomechanically determined factor, it can lead to hip destruction and early osteoarthritis in pincer-type impingement. The aim of this work was to study the biomechanism and stress-strain behavior of chondrolabral lesions in pincer-type impingement during daily activity-associated movements.

Neoadjuvant Osimertinib Followed by Sequential Definitive Radiation Therapy and/or Surgery in Stage III Epidermal Growth Factor Receptor-Mutant Non-Small Cell Lung Cancer: An Open-Label, Single-Arm, Phase 2 Study.

Purpose: The treatment for unresectable, locally advanced stage III non-small cell lung cancer (NSCLC) is concurrent chemoradiation therapy (CRT) followed by consolidation durvalumab. This study aimed to evaluate the benefit of neoadjuvant osimertinib as an alternative therapy to this approach with the aim of reducing the radiation field.

Methods And Materials: This investigation was a nonrandomized, open-label, single-arm, phase 2, prospective, proof-of-concept study.

Unusual temperature dependence of the fluorescence decay in heterostructured stilbene.

Fluorescence spectra as well as the fluorescence decay kinetics of hot-pressed and sublimated films of stilbene have been studied in a wide temperature range, from 15 K up to room temperature. The fluorescence decay kinetics demonstrate unusual elongation of the excitation lifetime with a temperature increase. This is in contrast to the corresponding data of stilbene solutions in chloroform and in a polystyrene (PS) matrix.