Publications by authors named "I D Hay"
These case studies explore the subjective visual experiences of individuals with cerebral visual impairment (CVI), specifically dorsal stream dysfunction (DSD) characterized by simultanagnosia. Through three in-depth case studies, this work documents the challenges these individuals face when navigating cluttered environments. The individuals were asked to describe their visual experiences while watching videos of varying complexity, with the future aim of creating a simulation of simultanagnosia.
View Article and Find Full Text PDFArticle Synopsis
- The phosphoinositide 3-kinase (PI3K) superfamily consists of lipid kinases and PI3K-like protein kinases that share a conserved C-terminal kinase domain, characterized by low basal activity that can be significantly enhanced by various regulatory factors.
- Activators induce conformational changes in the kinase domain that improve ATP-binding and catalysis efficiency, specifically through realignment of the active site and changes in a region known as the PIKK regulatory domain.
- A recent discovery of a small-molecule activator for PI3Kα may lead to the development of specific PI3K activators, with potential applications in wound healing, neurodegeneration treatment, and anti-stroke therapies.
Embryogenesis is a vulnerable time. Mutations in developmental cells can result in the wide dissemination of cells predisposed to disease within mature organs. We characterised the evolutionary history of four synchronous renal tumours from a 14-year-old girl using whole genome sequencing alongside single cell and bulk transcriptomic sequencing.
View Article and Find Full Text PDFAn overview of the development of pharmacotherapeutics targeting SARS-CoV-2.
Drug Discov Today
September 2024
Coronavirus disease 2019 (COVID-19) was declared a global pandemic in March 2020, which precipitated urgent public health responses. The causative agent, SARS-CoV-2, spreads primarily via respiratory droplets, necessitating precautions to mitigate transmission risks. Biopharmaceutical industries and academic institutions worldwide swiftly redirected their research endeavors towards developing therapeutic interventions, focusing on monoclonal antibodies, antiviral agents, and immunomodulatory therapies.
View Article and Find Full Text PDFObjective: Results of ethanol ablation (EA) for controlling neck nodal metastases (NNM) in adult patients with papillary thyroid carcinoma (APTC) beyond 6 months have rarely been reported. We now describe outcome results in controlling 71 NNM in 40 node-positive stage I APTC patients followed for 66 to 269 months.
Methods: All 40 patients were managed with bilateral thyroidectomy and radioiodine therapy and followed with neck ultrasound (US) for >48 months after EA.