Publications by authors named "I D Harrow"

Background: In 2012, Chicago Public Schools and the Chicago Department of Public Health partnered together to create the Chicago School-Based Vision Program (CSBVP). This ongoing, city-wide program provides school-based vision services (eye examinations, eyeglasses provision, and eye care referrals) to students with limited access.

Methods: Descriptive analysis of the program operations from 2012 to 2020, including number of students served and exam findings during 2017-2020, as well as lessons learned and recommendations for reproducing the successes of the CSBVP in other contexts.

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Despite progress in the development of standards for describing and exchanging scientific information, the lack of easy-to-use standards for mapping between different representations of the same or similar objects in different databases poses a major impediment to data integration and interoperability. Mappings often lack the metadata needed to be correctly interpreted and applied. For example, are two terms equivalent or merely related? Are they narrow or broad matches? Or are they associated in some other way? Such relationships between the mapped terms are often not documented, which leads to incorrect assumptions and makes them hard to use in scenarios that require a high degree of precision (such as diagnostics or risk prediction).

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Over recent years, there has been exciting growth in collaboration between academia and industry in the life sciences to make data more Findable, Accessible, Interoperable and Reusable (FAIR) to achieve greater value. Despite considerable progress, the transformative shift from an application-centric to a data-centric perspective, enabled by FAIR implementation, remains very much a work in progress on the 'FAIR journey'. In this review, we consider use cases for FAIR implementation.

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Article Synopsis
  • This review talks about how scientists are working on improving "ontology mapping," which helps them understand and organize large amounts of medical data better.
  • By doing this, they can make better discoveries, especially in finding new medicines using machine learning.
  • The review also looks at challenges they face, tools they can use, and their plans to create helpful services for ontology mapping in the future.
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Biopharmaceutical industry R&D, and indeed other life sciences R&D such as biomedical, environmental, agricultural and food production, is becoming increasingly data-driven and can significantly improve its efficiency and effectiveness by implementing the FAIR (findable, accessible, interoperable, reusable) guiding principles for scientific data management and stewardship. By so doing, the plethora of new and powerful analytical tools such as artificial intelligence and machine learning will be able, automatically and at scale, to access the data from which they learn, and on which they thrive. FAIR is a fundamental enabler for digital transformation.

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