Publications by authors named "I D Grigor'eva"

This article provides an overview of the metaanalyzes (PubMed, 19952019) of alcohol and non-alcoholic (coffee, tea, dairy products) beverage consumption in relation to risk of pancreatic cancer PC (PubMed, 19952019). Increased the PC risk was associated with high alcohol intake. The increased risk for heavy drinking did not explained by residual confounding by history of pancreatitis or tobacco smoking or diabetes.

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Aim: To identify and compare the frequency of alcohol consumption, tobacco smoking, levels of main macronutrients, vitamins and mineral elements consumption in patients with acute (AP) and chronic pancreatitis (CP) and pancreatic cancer (PC).

Materials And Methods: At the observational clinical cross-sectional uncontrolled case-study 65 patients with AP or CP (group 1) and 45 patients with PC (group 2) were examined. A survey of patients was carried out: questionnaire on tobacco smoking, a frequency questionnaire on alcohol consumption, a questionnaire for assessing the frequency of food consumption.

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The last decade saw extensive studies of the human gut microbiome and its relationship to specific diseases, including gallstone disease (GSD). The information about the gut microbiome in GSD-afflicted Russian patients is scarce, despite the increasing GSD incidence worldwide. Although the gut microbiota was described in some GSD cohorts, little is known regarding the gut microbiome before and after cholecystectomy (CCE).

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Obesity is a major risk factor for developing gallstone disease (GSD). Previous studies have shown that obesity is associated with an elevated ratio in the gut microbiota. These findings suggest that the development of GSD may be related to gut dysbiosis.

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Article Synopsis
  • Gallstone disease (GSD) is a significant public health issue linked to high costs and complications, with increasing evidence connecting the disease to the gut microbiota.
  • Studies show that bacteria in the mouth and gastrointestinal tract influence gallbladder motility and mucin gene expression, potentially promoting gallstone formation.
  • The impact of gallbladder removal on microbiota composition raises concerns about increased cancer risks, highlighting the need for further research on microbiota evaluation as a diagnostic tool for gastroenterological diseases.
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