LYMPHOTROPIC ADMINISTRATION OF ANTIBACTERIAL DRUGS - A METHOD OF RATIONAL ANTIBIOTIC THERAPY.

Objective: The aim: To explore the possibilities of rationalizing antibacterial therapy by comparative analysis of the accumulation of ceftriaxone administered lymphotropically and intramuscularly.

Patients And Methods: Materials and methods: The research used a method of studying the sensitivity of microorganisms to antibacterial drugs, which is based on the diffusion of antibacterial drugs from the carrier (homogenate of the test organ) in a dense nutrient medium, which, depending on the sensitivity of microorganisms, inhibits the growth of the studied culture and is accompanied by the formation of a growth inhibition zone (GIZ) in the nutrient medium. For control purposes, a commercial disk with ceftriaxone was used, which caused GIZ of microorganisms at the level of 27.

PARTICULAR QUALITIES OF THE PROTEOLYTIC SYSTEM IN PATIENTS WITH TUBERCULOSIS DEPENDING ON THE SENSITIVITY OF THE PATHOGEN.

Objective: The aim: Studying the features of the proteolytic system in patients with tuberculosis depending on the sensitivity of the pathogen.

Patients And Methods: Materials and methods: In the course of the research we studied the level of elastase in the blood of 111 patients. The first group consisted of 66 (59.

[ТRAUMAGENESIS, ЕPIDEMIOLOGICAL AND NOSOLOGICAL CHARACTERISTICS OF THE GUN-SHOT-EXPLOSIVE WOUNDINGS OF THE PEACE TIME IN CHILDREN].

Structure of the gun-shot-explosive woundings (GSEW) of the peacetime, occurred in 35 children, was analyzed with refinement, concerning a weapon kind and motif of application, as well as clinic-epidemiological and clinic-nosological characteristics of injuries. Аnalysis of the data was conducted in accordance to criteria and demands of evidence-based medicine, using the methods of nonparametric statistics and computeric technologies. Clinic-epidemiological characteristic of the wounded persons have had witnessed, that due to the GSEW accidents suffer children, ageing (11.

[WAYS OF THE SURGICAL MISTAKES OVERCOME IN THE PAIN ABDOMINAL AND THORACIC SYNDROMS].

Experience of differential diagnosis of pleural diseases, accompanied by pleuroabdominal pain syndrome, simulating «an acute abdomen», was summarized. In a pleural exudate syndrome such a course was noted in 17 (3%) patients, of them 7 (1.23%) were operated on; and in a syndrome of spontaneous pneumothorax – in 3 (1.

[HORMONALLY-GENETICALLY DEPENDENT THERAPY, USING VITAMIN K IN PATIENTS, SUFFERING THE ULCER HEMORRHAGE].

Pathophysiological mechanisms of the vitamin K impact, including those in the gut with ulcerative affection, are studied still insufficiently. Investigations of pharmacogenomics of the vitamin K gives a new approach to therapy in patients, suffering gastro-intestinal hemorrhage. Possibilities of titration of the vitamin K3 (menadione) doses, depending on level of estrogenemia and genetic constitution, concerning genes-candidates ESR1 (rs2234693) and VKORC1 (rs9923231), were studied.